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Etv4tm1Arbr
Targeted Allele Detail
Summary
Symbol: Etv4tm1Arbr
Name: ets variant 4; targeted mutation 1, Silvia Arber
MGI ID: MGI:2387770
Synonyms: Etv4-, Etv4lacZ, Pea3nlslacZ, Pea3NLZ
Gene: Etv4  Location: Chr11:101660568-101676197 bp, - strand  Genetic Position: Chr11, 65.48 cM
Alliance: Etv4tm1Arbr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78717
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA portion of exon 6 and all of exons 7 through 11 were replaced with a cassette containing IRES-NLS-lacZ followed by a polyadenylation signal and neo gene. (J:78717)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Allelic CompositionGenetic BackgroundCell Line(s)
involves: 129S1/Sv
 
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL
 
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL
 
involves: 129S1/Sv
 
involves: 129S1/Sv
 
involves: 129S1/Sv
 
involves: 129S1/Sv
 
involves: 129S1/Sv * 129S6/SvEvTac
 
involves: 129S1/Sv * 129S6/SvEvTac
 
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
 
involves: 129S1/Sv * C57BL/6J * CBA/J
 
Phenotypes:
Affected Systems
show or hide all annotated terms
                     
behavior/neurological
impaired limb coordination
embryo
abnormal limb bud morphology
growth/size/body
kidney cyst
limbs/digits/tail
abnormal limb bud morphology
polyphalangy
polydactyly
preaxial polydactyly
mortality/aging
lethality throughout fetal growth and development, complete penetrance
neonatal lethality, complete penetrance
muscle
decreased muscle spindle number
nervous system
abnormal innervation pattern to muscle
abnormal motor neuron morphology
abnormal motor neuron innervation pattern
decreased motor neuron number
abnormal somatic sensory system morphology
decreased muscle spindle number
decreased sensory neuron number
abnormal proprioceptive neuron morphology
decreased pacinian corpuscle number
small pacinian corpuscles
renal/urinary system
abnormal kidney morphology
kidney cyst
renal hypoplasia
abnormal nephron morphology
decreased renal glomerulus number
decreased renal tubule number
absent kidney
abnormal ureter development
absent ureter
skeleton
polyphalangy
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 32 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Etv4tm1Arbr
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Etv4 Mutation:  41 strains or lines available
References
Original:  J:78717 Livet J, et al., ETS gene Pea3 controls the central position and terminal arborization of specific motor neuron pools. Neuron. 2002 Aug 29;35(5):877-92
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory