Tg(Thy1-Serpine2)2Dmn
Transgene Detail

Summary

• Symbol: Tg(Thy1-Serpine2)2Dmn
• Name: transgene insertion 2, Denis Monard
• MGI ID: MGI:2387772
• Synonyms: T2, Thy 1/PN-1
• Transgene: Tg(Thy1-Serpine2)2Dmn Location: unknown
• Alliance: Tg(Thy1-Serpine2)2Dmn page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-Serpine2)2Dmn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Serpine2 (29366)

  Serpine2

  (MGI:101780)

• Mutation details: The transgene consists of mouse Thy1 regulatory sequences fused to rat Serpine2 cDNA. The mouse Thy1 promoter was used to drive expression of the transgene in the CNS. Transgene expression was detected in the brain, and a low level of transgene expression was detected in the lungs. (J:40953)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgenic line T2 expressed rat Serpine2 mRNA and protein at high levels in the brain (2-fold higher compared to transgenic line T1).

References

• Original: J:40953 Luthi A, et al., Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation. J Neurosci. 1997 Jun 15;17(12):4688-99
• All: 2 reference(s)