Serpine2^tm1Dmn
Targeted Allele Detail

Summary

• Symbol: Serpine2^tm1Dmn
• Name: serine (or cysteine) peptidase inhibitor, clade E, member 2; targeted mutation 1, Denis Monard
• MGI ID: MGI:2387774
• Synonyms: PN-1^-, SE2^-
• Gene: Serpine2 Location: Chr1:79772038-79836382 bp, - strand Genetic Position: Chr1, 40.97 cM
• Alliance: Serpine2^tm1Dmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40953
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 2 via homologous recombination. The targeted mutation removes 99 bp of exon 2 including the translation initiation codon. Absence of gene expression in homozygous mutant animals was confirmed by Nothern blot and Western blot analysis of brain samples. (J:40953)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpine2 Mutation: 26 strains or lines available

References

• Original: J:40953 Luthi A, et al., Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation. J Neurosci. 1997 Jun 15;17(12):4688-99
• All: 15 reference(s)