Tnfrsf17^tm1Kplm
Targeted Allele Detail

Summary

• Symbol: Tnfrsf17^tm1Kplm
• Name: tumor necrosis factor receptor superfamily, member 17; targeted mutation 1, Kong-Peng Lam
• MGI ID: MGI:2387797
• Synonyms: BCMA^-
• Gene: Tnfrsf17 Location: Chr16:11131676-11137938 bp, + strand Genetic Position: Chr16, 6.42 cM, cytoband B3
• Alliance: Tnfrsf17^tm1Kplm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69599
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 3 with a neomycin resistance cassette via homologous recombination. The mutation deletes amino acids 119-143 which includes most of the intracellular domain, a region involved in binding TNF receptor-associated factors. (J:69599)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf17 Mutation: 21 strains or lines available

References

• Original: J:69599 Xu S, et al., B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. Mol Cell Biol. 2001 Jun;21(12):4067-74
• All: 6 reference(s)