Cacna1b^tm1Ttan
Targeted Allele Detail

Summary

• Symbol: Cacna1b^tm1Ttan
• Name: calcium channel, voltage-dependent, N type, alpha 1B subunit; targeted mutation 1, Tsutomu Tanabe
• MGI ID: MGI:2387803
• Synonyms: Cav2.2-
• Gene: Cacna1b Location: Chr2:24493899-24653164 bp, - strand Genetic Position: Chr2, 16.58 cM, cytoband A2
• Alliance: Cacna1b^tm1Ttan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69585
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 with an in-frame lacZ-neo cassette. The null allele was confirmed by Northern blot, RT-PCR, and Western blot analysis of brain samples taken from homozygous mutant animals. (J:69585)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacna1b Mutation: 104 strains or lines available

References

• Original: J:69585 Saegusa H, et al., Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel. EMBO J. 2001 May 15;20(10):2349-56
• All: 4 reference(s)