Ptf1a^{tm1.1(cre)Cvw}
Targeted Allele Detail

Summary

• Symbol: Ptf1a^{tm1.1(cre)Cvw}
• Name: pancreas specific transcription factor, 1a; targeted mutation 1.1, Christopher VE Wright
• MGI ID: MGI:2387812
• Synonyms: P48-Cre, P48^Cre, Ptf1a-cre, Ptf1a^Cre, Ptf1a^tm1(cre)Wri
• Gene: Ptf1a Location: Chr2:19450474-19452312 bp, + strand Genetic Position: Chr2, 13.37 cM, cytoband A2
• Alliance: Ptf1a^{tm1.1(cre)Cvw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78710
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Ptf1a^{tm1.1(cre)Cvw} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ptf1a (MGI:1328312)

• Mutation details: The floxed neo cassette was excised from mice carrying Ptf1a^tm1(cre)Cvw by in vivo cre mediated recombination. The previously inserted cre recombinase remained in place of the entire endogenous coding region. (J:78710)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ptf1a (mouse) Summary of all recombinase alleles driven by Ptf1a. Comparative matrix view of recombinase activities Alliance mouse Ptf1a gene page

Disease models

Expression

In Mice Carrying this Mutation:	255 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptf1a^{tm1.1(cre)Cvw}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptf1a Mutation: 31 strains or lines available

References

• Original: J:78710 Kawaguchi Y, et al., The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet. 2002 Sep;32(1):128-34
• All: 308 reference(s)