Vav2^tm1Kdf
Targeted Allele Detail

Summary

• Symbol: Vav2^tm1Kdf
• Name: vav 2 oncogene; targeted mutation 1, Klaus-Dieter Fischer
• MGI ID: MGI:2387822
• Synonyms: Vav-2^-
• Gene: Vav2 Location: Chr2:27152116-27317045 bp, - strand Genetic Position: Chr2, 19.36 cM
• Alliance: Vav2^tm1Kdf page

Vav2^tm1Kdf/Vav2^tm1Kdf Vav3^tm1Swat/Vav3^tm1Swat mice develop buphthalmos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69806
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ-neo cassette was fused in-frame to amino acids 150-155 of exon 5 and introduced via homologous recombination. Western blot analysis of spleen tissue from homozygous mutant animals confirmed the absence of gene expression. (J:69806)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vav2 Mutation: 45 strains or lines available

References

• Original: J:69806 Tedford K, et al., Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Nat Immunol. 2001 Jun;2(6):548-55
• All: 20 reference(s)