Mixl1^tm1.1Robb
Targeted Allele Detail

Summary

• Symbol: Mixl1^tm1.1Robb
• Name: Mix paired-like homeobox; targeted mutation 1.1, Lorraine Robb
• MGI ID: MGI:2387829
• Synonyms: Mixl1^deltaneo
• Gene: Mixl1 Location: Chr1:180520608-180524599 bp, - strand Genetic Position: Chr1, 84.46 cM
• Alliance: Mixl1^tm1.1Robb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77443
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Disruption caused by insertion of vector
• Mutation details: The floxed neo cassette was excised from Mixl1^tm1Robb via in vivo cre mediated recombination. The previously inserted GFP sequence remained in place of the coding region of exon 1. (J:77443)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mixl1 Mutation: 20 strains or lines available

References

• Original: J:77443 Hart AH, et al., Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. Development. 2002 Aug;129(15):3597-608
• All: 2 reference(s)