Clip2^tm1.1Gal
Targeted Allele Detail

Summary

• Symbol: Clip2^tm1.1Gal
• Name: CAP-GLY domain containing linker protein 2; targeted mutation 1.1, Niels Galjart
• MGI ID: MGI:2387833
• Synonyms: CLIP-L
• Gene: Clip2 Location: Chr5:134518237-134581288 bp, - strand Genetic Position: Chr5, 74.63 cM, cytoband G
• Alliance: Clip2^tm1.1Gal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78711
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: ES cells containing Cyln2^tm1Gal were electroporated with a construct containing cre recombinase and a hygromycin resistance gene. Expression of cre resulted in the excision of the floxed region containing both previously inserted selection genes and exons 3 through 17. Neither normal transcript nor normal protein was detected in homozygous mutant mice by Northern and Western blot analyses. Recombination left the previously inserted lacZ gene in frame with the endogenous promoter, which drove its expression. (J:78711)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clip2 Mutation: 61 strains or lines available

References

• Original: J:78711 Hoogenraad CC, et al., Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice. Nat Genet. 2002 Sep;32(1):116-27
• All: 3 reference(s)