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Hdac9tm1Eno
Targeted Allele Detail
Summary
Symbol: Hdac9tm1Eno
Name: histone deacetylase 9; targeted mutation 1, Eric N Olson
MGI ID: MGI:2387834
Synonyms: HDAC9-
Gene: Hdac9  Location: Chr12:34097579-34967094 bp, - strand  Genetic Position: Chr12, 15.06 cM, cytoband B2
Alliance: Hdac9tm1Eno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78734
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMost of exon 4 and all of exon 5 were replaced by a cassette containing lacZ and neo inserted by homologous recombination. The deleted region encoded amino acids 99 through 176, encompassing the MEF2 binding domain, thus affecting the predominate MEF2-interacting transcriptional repressor (MITR) splice form. RT-PCR and sequence analysis of mutant mice identified aberrant transcript in which the inserted cassette was excised and exon 3 had spliced to exon 6. This alternate splice pattern introduced two stop codons immediately downstream of exon 3, and therefore precluded the translation of normal protein. (J:78734)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hdac9 Mutation:  51 strains or lines available
References
Original:  J:78734 Zhang CL, et al., Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell. 2002 Aug 23;110(4):479-88
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory