Hdac9tm1Eno
Targeted Allele Detail
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Symbol: |
Hdac9tm1Eno |
Name: |
histone deacetylase 9; targeted mutation 1, Eric N Olson |
MGI ID: |
MGI:2387834 |
Synonyms: |
HDAC9- |
Gene: |
Hdac9 Location: Chr12:34097579-34967094 bp, - strand Genetic Position: Chr12, 15.06 cM, cytoband B2
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Alliance: |
Hdac9tm1Eno page
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Most of exon 4 and all of exon 5 were replaced by a cassette containing lacZ and neo inserted by homologous recombination. The deleted region encoded amino acids 99 through 176, encompassing the MEF2 binding domain, thus affecting the predominate MEF2-interacting transcriptional repressor (MITR) splice form. RT-PCR and sequence analysis of mutant mice identified aberrant transcript in which the inserted cassette was excised and exon 3 had spliced to exon 6. This alternate splice pattern introduced two stop codons immediately downstream of exon 3, and therefore precluded the translation of normal protein.
(J:78734)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hdac9 Mutation: |
51 strains or lines available
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Original: |
J:78734 Zhang CL, et al., Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell. 2002 Aug 23;110(4):479-88 |
All: |
17 reference(s) |
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