Odc1^tm1Jlc
Targeted Allele Detail

Summary

• Symbol: Odc1^tm1Jlc
• Name: ornithine decarboxylase, structural 1; targeted mutation 1, John L Cleveland
• MGI ID: MGI:2387837
• Synonyms: ODC^-
• Gene: Odc1 Location: Chr12:17594906-17601503 bp, + strand Genetic Position: Chr12, 8.11 cM
• Alliance: Odc1^tm1Jlc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71462
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 2 and all of exon 3 were replaced with an IRES-lacz-neo cassette. The deleted region encoded the first 35 amino acids of the endogenous protein, including the initiator methionine. A biochemical assay of extracts obtained from MEFs derived from heterozygous animals, showed enzymatic activity to be reduced by approximately half. (J:71462)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Odc1 Mutation: 36 strains or lines available

References

• Original: J:71462 Pendeville H, et al., The ornithine decarboxylase gene is essential for cell survival during early murine development. Mol Cell Biol. 2001 Oct;21(19):6549-58
• All: 5 reference(s)