Vav1^tm2Bbd
Targeted Allele Detail

Summary

• Symbol: Vav1^tm2Bbd
• Name: vav 1 oncogene; targeted mutation 2, Mariano Barbacid
• MGI ID: MGI:2387840
• Synonyms: vav^-
• Gene: Vav1 Location: Chr17:57586100-57635031 bp, + strand Genetic Position: Chr17, 29.76 cM
• Alliance: Vav1^tm2Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47596
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences encoding amino acids 135-195 comprising the entire acidic domain were replaced with a PGK-neo cassette via homologous recombination. Gene expression was absent in thymocytes of homozygous mutant animals. (J:47596)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vav1 Mutation: 60 strains or lines available

References

• Original: J:47596 Fischer KD, et al., Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol. 1998 May 7;8(10):554-62
• All: 16 reference(s)