Brs3^tm1Hoh
Targeted Allele Detail

Summary

• Symbol: Brs3^tm1Hoh
• Name: bombesin-like receptor 3; targeted mutation 1, Hiroko Ohki-Hamazaki
• MGI ID: MGI:2387858
• Synonyms: BRS-3-deficient
• Gene: Brs3 Location: ChrX:56088434-56094118 bp, + strand Genetic Position: ChrX, 30.78 cM, cytoband A7.1-A7.2
• Alliance: Brs3^tm1Hoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44242
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by with a neomycin selection cassette inserted via homologous recombination. Transcript was undetected in hemizygous mutant mice via RT-PCR analysis. (J:44242)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brs3 Mutation: 14 strains or lines available

References

• Original: J:44242 Ohki-Hamazaki H, et al., Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. Nature. 1997 Nov 13;390(6656):165-9
• All: 7 reference(s)