Omp^tm1Flm
Targeted Allele Detail

Summary

• Symbol: Omp^tm1Flm
• Name: olfactory marker protein; targeted mutation 1, Frank L Margolis
• MGI ID: MGI:2387862
• Gene: Omp Location: Chr7:97792566-97794654 bp, - strand Genetic Position: Chr7, 53.59 cM
• Alliance: Omp^tm1Flm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36149
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the endogenous locus was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis of homozygous mutant mice showed an absence of protein in olfactory epithelium and olfactory bulbs. ELISA showed the protein level in heterozygous mice to be 40-50% of that in wild-type mice. (J:36149)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Omp Mutation: 27 strains or lines available

References

• Original: J:36149 Buiakova OI, et al., Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9858-63
• All: 8 reference(s)