Ogt^tm1Gwh
Targeted Allele Detail

Summary

• Symbol: Ogt^tm1Gwh
• Name: O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); targeted mutation 1, Gerald W Hart
• MGI ID: MGI:2387867
• Synonyms: OGT^F
• Gene: Ogt Location: ChrX:100683666-100727957 bp, + strand Genetic Position: ChrX, 44.45 cM, cytoband D
• Alliance: Ogt^tm1Gwh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62279
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The exon encoding amino acids 206 through 232 (numbering derived from the rat cDNA encoding 1037 residues) was flanked by single loxP sites. (J:62279)

Expression

In Mice Carrying this Mutation:	4 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ogt Mutation: 12 strains or lines available

References

• Original: J:62279 Shafi R, et al., The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5735-9
• All: 64 reference(s)