Oprd1^tm1Jep
Targeted Allele Detail

Summary

• Symbol: Oprd1^tm1Jep
• Name: opioid receptor, delta 1; targeted mutation 1, John E Pintar
• MGI ID: MGI:2387891
• Synonyms: DOR-1 KO, DOR-KO
• Gene: Oprd1 Location: Chr4:131838037-131871797 bp, - strand Genetic Position: Chr4, 64.78 cM, cytoband D1-D3
• Alliance: Oprd1^tm1Jep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57886
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by a neomycin selection cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice using an antiserum directed against the amino terminal. Furthermore, an absence of ligand binding was determined via autoradiographic analysis of radiolabeled ligands that preferentially bind to the pharmacologically defined receptors, delta1 and delta2. (J:57886)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oprd1 Mutation: 30 strains or lines available

References

• Original: J:57886 Zhu Y, et al., Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice. Neuron. 1999 Sep;24(1):243-52
• All: 8 reference(s)