Drd2^tm1Ebo
Targeted Allele Detail

Summary

• Symbol: Drd2^tm1Ebo
• Name: dopamine receptor D2; targeted mutation 1, Emiliana Borrelli
• MGI ID: MGI:2387895
• Synonyms: D2R^-
• Gene: Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
• Alliance: Drd2^tm1Ebo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29045
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which contains the translational start codon, was replaced by a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by Northern blot analysis of RNA isolated from striata. An absence of functional protein was determined by radiolabeled ligand binding analyses. (J:29045)

Disease models

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drd2 Mutation: 70 strains or lines available

References

• Original: J:29045 Baik JH, et al., Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature. 1995 Oct 5;377(6548):424-8
• All: 35 reference(s)