Mmp11^tm1Mrio
Targeted Allele Detail

Summary

• Symbol: Mmp11^tm1Mrio
• Name: matrix metallopeptidase 11; targeted mutation 1, Marie-Christine Rio
• MGI ID: MGI:2387934
• Synonyms: ST3^-
• Gene: Mmp11 Location: Chr10:75759056-75768336 bp, - strand Genetic Position: Chr10, 38.62 cM
• Alliance: Mmp11^tm1Mrio page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79012
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of exons 2 through 6 and 5' portion of exon 7 were replaced by a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of RNA isolated from involuting uteri of homozygous mutant mice. (J:79012)

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp11 Mutation: 34 strains or lines available

References

• Original: J:79012 Masson R, et al., In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy. J Cell Biol. 1998 Mar 23;140(6):1535-41
• All: 7 reference(s)