Msh2^tm1Whl
Targeted Allele Detail

Summary

• Symbol: Msh2^tm1Whl
• Name: mutS homolog 2; targeted mutation 1, Wen-Hwa Lee
• MGI ID: MGI:2387935
• Synonyms: Msh2^-
• Gene: Msh2 Location: Chr17:87979960-88031141 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Msh2^tm1Whl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79016
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3' portion of exon 3 was replaced by a neomycin selection cassette inserted by homologous recombination. (J:79016)

Tumor Data

List all tumor models in MMHCdb carrying Msh2^tm1Whl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msh2 Mutation: 95 strains or lines available

References

• Original: J:79016 Nikitin AY, et al., Cell Lineage-specific Effects Associated with Multiple Deficiencies of Tumor Susceptibility Genes in Msh2(-/-)Rb(+/-) Mice. Cancer Res. 2002 Sep 15;62(18):5134-8
• All: 2 reference(s)