Hey2^tm1Gess
Targeted Allele Detail

Summary

• Symbol: Hey2^tm1Gess
• Name: hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 1, Manfred Gessler
• MGI ID: MGI:2387937
• Synonyms: Hey2 -
• Gene: Hey2 Location: Chr10:30708355-30718779 bp, - strand Genetic Position: Chr10, 17.19 cM, cytoband A4
• Alliance: Hey2^tm1Gess page

Ventricular and atrial septal defects in Hey2^tm1Gess/Hey2^tm1Gess mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79024
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3' portion of exon 2 and all of exon 3 were replaced with a lacZ cassette inserted by homologous recombination. The expression pattern of the fusion protein containing the lacZ sequence was similar to that of the normal protein. In situ hybridization indicated that the inserted cassette precluded the transcription of downstream sequence. (J:79024)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hey2 Mutation: 31 strains or lines available

References

• Original: J:79024 Gessler M, et al., Mouse gridlock. No Aortic Coarctation or Deficiency, but Fatal Cardiac Defects in Hey2 -/- Mice. Curr Biol. 2002 Sep 17;12(18):1601
• All: 11 reference(s)