Hey2^tm1Uts
Targeted Allele Detail

Summary

• Symbol: Hey2^tm1Uts
• Name: hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 1, Manuel F Utset
• MGI ID: MGI:2387940
• Synonyms: Hey2^lacZ
• Gene: Hey2 Location: Chr10:30708355-30718779 bp, - strand Genetic Position: Chr10, 17.19 cM, cytoband A4
• Alliance: Hey2^tm1Uts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79025
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment, extending from codon 19 in exon 1 through a portion of exon 3, was replaced with a cassette containing lacZ and neo. The deleted region encoded the basic helix-loop-helix, Orange, and YXXW domains. The expression pattern of the fusion protein containing lacZ was similar to that of the endogenous pattern. (J:79025)

Disease models

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hey2 Mutation: 31 strains or lines available

References

• Original: J:79025 Donovan J, et al., Tetralogy of fallot and other congenital heart defects in hey2 mutant mice. Curr Biol. 2002 Sep 17;12(18):1605
• All: 1 reference(s)