Bcl2l10^tm1Pmc
Targeted Allele Detail

Summary

• Symbol: Bcl2l10^tm1Pmc
• Name: Bcl2-like 10; targeted mutation 1, Peter J McKinnon
• MGI ID: MGI:2387943
• Synonyms: Diva^-
• Gene: Bcl2l10 Location: Chr9:75255040-75258922 bp, + strand Genetic Position: Chr9, 42.3 cM, cytoband D
• Alliance: Bcl2l10^tm1Pmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78924
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced by a neomycin selection cassette inserted by homologous recombination. The deleted region encompassed the entire coding region of the endogenous locus, thus transcript was undetected by Northern blot analysis of ovarian RNA obtained from homozygous mutant mice. (J:78924)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2l10 Mutation: 6 strains or lines available

References

• Original: J:78924 Russell HR, et al., Murine ovarian development is not affected by inactivation of the bcl-2 family member diva. Mol Cell Biol. 2002 Oct;22(19):6866-70
• All: 1 reference(s)