Iqgap1^tm1Aber
Targeted Allele Detail

Summary

• Symbol: Iqgap1^tm1Aber
• Name: IQ motif containing GTPase activating protein 1; targeted mutation 1, Andre Bernards
• MGI ID: MGI:2387945
• Synonyms: Iqgap1^-
• Gene: Iqgap1 Location: Chr7:80361331-80453288 bp, - strand Genetic Position: Chr7, 45.68 cM
• Alliance: Iqgap1^tm1Aber page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59215
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of a 233 bp coding exon with a PGK-neo cassette in the reverse orientation. Complete absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of adult and embyronic tissues using antibodies raised against the N-terminal, central, and C-terminal regions of the protein. (J:59215)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Iqgap1 Mutation: 102 strains or lines available

References

• Original: J:59215 Li S, et al., Gastric hyperplasia in mice lacking the putative cdc42 effector IQGAP1. Mol Cell Biol. 2000 Jan;20(2):697-701
• All: 34 reference(s)