Mslntm1Ipa
Targeted Allele Detail
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Symbol: |
Mslntm1Ipa |
Name: |
mesothelin; targeted mutation 1, Ira Pastan |
MGI ID: |
MGI:2387955 |
Synonyms: |
Meso - |
Gene: |
Msln Location: Chr17:25967587-25973352 bp, - strand Genetic Position: Chr17, 12.85 cM, cytoband A3.3
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Alliance: |
Mslntm1Ipa page
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Germline Transmission: |
Earliest citation of germline transmission:
J:61336
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The gene was disrupted by replacement of sequences spanning exon 1 to intron 3 with a neomycin resistance cassette. The mutation deletes amino acids 20-100. Northern blot and RT-PCR analysis of lung samples from homozygous mutant animals did not detect gene expression. In situ hybridization of various tissues from homozygous animals using antibodies against the protein confirmed the null allele.
(J:61336)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Msln Mutation: |
38 strains or lines available
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Original: |
J:61336 Bera TK, et al., Mesothelin is not required for normal mouse development or reproduction. Mol Cell Biol. 2000 Apr;20(8):2902-6 |
All: |
5 reference(s) |
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