Kcnc2tm1Rudy
Targeted Allele Detail
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Symbol: |
Kcnc2tm1Rudy |
Name: |
potassium voltage gated channel, Shaw-related subfamily, member 2; targeted mutation 1, Bernardo Rudy |
MGI ID: |
MGI:2387957 |
Synonyms: |
Kv3.2 - |
Gene: |
Kcnc2 Location: Chr10:112107026-112302929 bp, + strand Genetic Position: Chr10, 60.3 cM
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Alliance: |
Kcnc2tm1Rudy page
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 3' portion of exon 1, encoding the tetramerization domain (T domain) involved in oligomerization of potassium voltage gated channel subunits, was replaced by a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern and Western blot analyses of homozygous mutant mice.
(J:66730)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Phenotypes: |
Affected Systems |
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behavior/neurological
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increased anxiety-related response
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abnormal sleep pattern
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seizures
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increased susceptibility to pharmacologically induced seizures
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myoclonus
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tonic-clonic seizures
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sporadic seizures
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muscle
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myoclonus
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nervous system
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seizures
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increased susceptibility to pharmacologically induced seizures
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√
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myoclonus
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√
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tonic-clonic seizures
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√
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sporadic seizures
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√
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abnormal nervous system electrophysiology
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abnormal action potential
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abnormal afterhyperpolarization
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abnormal brain wave pattern
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kcnc2 Mutation: |
30 strains or lines available
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Original: |
J:66730 Lau D, et al., Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking kv3.2 K+ channel proteins. J Neurosci. 2000 Dec 15;20(24):9071-85 |
All: |
8 reference(s) |
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