Kcnc2^tm1Rudy
Targeted Allele Detail

Summary

• Symbol: Kcnc2^tm1Rudy
• Name: potassium voltage gated channel, Shaw-related subfamily, member 2; targeted mutation 1, Bernardo Rudy
• MGI ID: MGI:2387957
• Synonyms: Kv3.2 -
• Gene: Kcnc2 Location: Chr10:112107026-112302929 bp, + strand Genetic Position: Chr10, 60.3 cM
• Alliance: Kcnc2^tm1Rudy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66730
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3' portion of exon 1, encoding the tetramerization domain (T domain) involved in oligomerization of potassium voltage gated channel subunits, was replaced by a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern and Western blot analyses of homozygous mutant mice. (J:66730)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnc2 Mutation: 30 strains or lines available

References

• Original: J:66730 Lau D, et al., Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking kv3.2 K+ channel proteins. J Neurosci. 2000 Dec 15;20(24):9071-85
• All: 8 reference(s)