Scn7a^tm1Mno
Targeted Allele Detail

Summary

• Symbol: Scn7a^tm1Mno
• Name: sodium channel, voltage-gated, type VII, alpha; targeted mutation 1, Masaharu Noda
• MGI ID: MGI:2387958
• Synonyms: mNav2^-, Nax^-, Nax-KO
• Gene: Scn7a Location: Chr2:66503770-66615254 bp, - strand Genetic Position: Chr2, 39.21 cM
• Alliance: Scn7a^tm1Mno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65133
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of an in-frame lacZ-neo cassette into exon 1. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of lung tissue. X-gal staining showed that lacZ reporter expression is directed by regulatory elements of the targeted gene. (J:65133)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn7a Mutation: 106 strains or lines available

References

• Original: J:65133 Watanabe E, et al., Nav2/NaG channel is involved in control of salt-intake behavior in the CNS. J Neurosci. 2000 Oct 15;20(20):7743-51
• All: 15 reference(s)