Grin3a^tm1Nnk
Targeted Allele Detail

Summary

• Symbol: Grin3a^tm1Nnk
• Name: glutamate receptor ionotropic, NMDA3A; targeted mutation 1, Nobuki Nakanishi
• MGI ID: MGI:2387963
• Synonyms: NR3A-
• Gene: Grin3a Location: Chr4:49661611-49845744 bp, - strand Genetic Position: Chr4, 26.72 cM
• Alliance: Grin3a^tm1Nnk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66481
• Parent Cell Line: C1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region encoding the N-terminal 118 amino acids (including the translation initation codon) was replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant animals lacked gene expression as demonstrated by Northern and Western blot analysis of brain samples. (J:66481)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin3a Mutation: 50 strains or lines available

References

• Original: J:66481 Das S, et al., Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature. 1998 May 28;393(6683):377-81
• All: 24 reference(s)