Tcl1^tm1Rso
Targeted Allele Detail

Summary

• Symbol: Tcl1^tm1Rso
• Name: T cell lymphoma breakpoint 1; targeted mutation 1, Giandomenico Russo
• MGI ID: MGI:2387964
• Synonyms: Tcl1^-
• Gene: Tcl1 Location: Chr12:105183012-105188996 bp, - strand Genetic Position: Chr12, 55.28 cM
• Alliance: Tcl1^tm1Rso page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78910
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were replaced by a neomycin selection cassette inserted by homologous recombination. (J:78910)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tcl1 Mutation: 11 strains or lines available

References

• Original: J:78910 Narducci MG, et al., TCL1 participates in early embryonic development and is overexpressed in human seminomas. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11712-7
• All: 8 reference(s)