Fxyd4^tm1Grt
Targeted Allele Detail

Summary

• Symbol: Fxyd4^tm1Grt
• Name: FXYD domain-containing ion transport regulator 4; targeted mutation 1, Haim Garty
• MGI ID: MGI:2387972
• Synonyms: CHIF -, CHIF KO
• Gene: Fxyd4 Location: Chr6:117910520-117914653 bp, - strand Genetic Position: Chr6, 55.7 cM
• Alliance: Fxyd4^tm1Grt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78904
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 5, encoding amino acids 1 through 33, were replaced with a neomycin selection cassette inserted by homologous recombination. The absence of transcript and protein in homozygous mutant mice was verified by Northern and Western blot analyses. (J:78904)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fxyd4 Mutation: 7 strains or lines available

References

• Original: J:78904 Aizman R, et al., Generation and phenotypic analysis of CHIF knockout mice. Am J Physiol Renal Physiol. 2002 Sep;283(3):F569-77
• All: 2 reference(s)