Nrcam^tm1Gmt
Targeted Allele Detail

Summary

• Symbol: Nrcam^tm1Gmt
• Name: neuronal cell adhesion molecule; targeted mutation 1, Martin Grumet
• MGI ID: MGI:2387976
• Synonyms: Nr-CAM
• Gene: Nrcam Location: Chr12:44375668-44648747 bp, + strand Genetic Position: Chr12, 20.71 cM
• Alliance: Nrcam^tm1Gmt page

Lobes IV and V of the cerebellum are smaller in Nrcam^tm1Gmt/Nrcam^tm1Gmt mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71828
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which contains the initiation codon, was replaced with a neomycin selection cassette. Western blot analysis on brain extracts derived from adult homozygous mice confirmed that no detectable protein was made from this allele. (J:71828)

Disease models

Expression

In Mice Carrying this Mutation:	35 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrcam Mutation: 87 strains or lines available

References

• Original: J:71828 Sakurai T, et al., Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development. J Cell Biol. 2001 Sep 17;154(6):1259-73
• All: 19 reference(s)