Mxd1^tm1Rne
Targeted Allele Detail

Summary

• Symbol: Mxd1^tm1Rne
• Name: MAX dimerization protein 1; targeted mutation 1, Robert N Eisenman
• MGI ID: MGI:2387993
• Synonyms: Mad1^tm1
• Gene: Mxd1 Location: Chr6:86624026-86646099 bp, - strand Genetic Position: Chr6, 37.75 cM
• Alliance: Mxd1^tm1Rne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45945
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing the 5' untranslated region and exon 1 were replaced by a PGK-neo cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of a variety of tissues obtained from homozygous mutant mice. (J:45945)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mxd1 Mutation: 17 strains or lines available

References

• Original: J:45945 Foley KP, et al., Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation. EMBO J. 1998 Feb 2;17(3):774-85
• All: 3 reference(s)