Zfr^tm1Reb
Targeted Allele Detail

Summary

• Symbol: Zfr^tm1Reb
• Name: zinc finger RNA binding protein; targeted mutation 1, Robert E Braun
• MGI ID: MGI:2387996
• Gene: Zfr Location: Chr15:12117917-12185769 bp, + strand Genetic Position: Chr15, 5.9 cM, cytoband A
• Alliance: Zfr^tm1Reb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68369
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 6.6 kb region of the gene encoding zinc fingers 1 and 2 was replaced with a promoter-less lacZ-neo cassette via homologous recombination. The mutation results in deletion of 3 exons, disruption of downstream sequences, and fusion of lacZ in-frame to the Zfr sequence. Immunostaining of E5.5 homozygous mutant embryos did not detect gene product. (J:68369)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfr Mutation: 63 strains or lines available

References

• Original: J:68369 Meagher MJ, et al., Requirement for the murine zinc finger protein ZFR in perigastrulation growth and survival. Mol Cell Biol. 2001 Apr;21(8):2880-90
• All: 1 reference(s)