Adipoq^tm1Chan
Targeted Allele Detail

Summary

• Symbol: Adipoq^tm1Chan
• Name: adiponectin, C1Q and collagen domain containing; targeted mutation 1, Lawrence Chan
• MGI ID: MGI:2388007
• Synonyms: Ad^-, Adipo^-, ADN^-
• Gene: Adipoq Location: Chr16:22965286-22976718 bp, + strand Genetic Position: Chr16, 13.96 cM, cytoband B3-B4
• Alliance: Adipoq^tm1Chan page

A basal-like subtype of mammary tumors in Adipoq^tm1Chan/Adipoq⁺ Tg(MMTV-PyVT)634Mul/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79122
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by a floxed neo cassette inserted by homologous recombination. Transcript was undetected in adipose tissue by Northern blot analysis of homozygous mutant mice. The lack of immunoreactivity by Western blot analysis using a carboxy terminal antibody indicated an absence of normal and truncated protein. (J:79122)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Adipoq^tm1Chan

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adipoq Mutation: 41 strains or lines available

References

• Original: J:79122 Ma K, et al., Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem. 2002 Sep 20;277(38):34658-61
• All: 107 reference(s)