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Tg(tetO-Vegfa)1Kesh
Transgene Detail
Summary
Symbol: Tg(tetO-Vegfa)1Kesh
Name: transgene insertion 1, Eli Keshet
MGI ID: MGI:2388011
Synonyms: pTET-VEGF, tet(0)-sflt-1, TET-VEGF165
Transgene: Tg(tetO-Vegfa)1Kesh  Location: unknown  
Alliance: Tg(tetO-Vegfa)1Kesh page
Transgene
origin
Strain of Origin:  Not Applicable
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Tg(tetO-Vegfa)1Kesh expresses 1 gene
 
Mutation detailsThe full-length mouse Vegfa cDNA fused to a tetracycline-responsive cytomegalovirus promoter was used as the transgene. (J:68214)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tg(tetO-Vegfa)1Kesh
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
The glioma cell line C6 was used for transgene injection. The construct was originally described in Benjamin and Keshet, 1997, PNAS 94, 8761-8766.
References
Original:  J:68214 Dor Y, et al., A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects. Development. 2001 May;128(9):1531-8
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory