Numb^tm1Zili
Targeted Allele Detail

Summary

• Symbol: Numb^tm1Zili
• Name: NUMB endocytic adaptor protein; targeted mutation 1, Olav Zilian
• MGI ID: MGI:2388022
• Synonyms: numb^flox, Numb^neo-lox
• Gene: Numb Location: Chr12:83840808-83968708 bp, - strand Genetic Position: Chr12, 38.89 cM, cytoband D3
• Alliance: Numb^tm1Zili page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68652
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1 was flanked with loxP sites by insertion of a floxed PGK-neo cassette and a single loxP site into the upstream and downstream introns, respectively. (J:68652)

Expression

In Mice Carrying this Mutation:	27 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Numb Mutation: 59 strains or lines available

References

• Original: J:68652 Zilian O, et al., Multiple roles of mouse Numb in tuning developmental cell fates. Curr Biol. 2001 Apr 3;11(7):494-501
• All: 29 reference(s)