Ddr1^tm1Wfv
Targeted Allele Detail

Summary

• Symbol: Ddr1^tm1Wfv
• Name: discoidin domain receptor family, member 1; targeted mutation 1, Wolfgang F Vogel
• MGI ID: MGI:2388024
• Synonyms: DDR1^-
• Gene: Ddr1 Location: Chr17:35992459-36015513 bp, - strand Genetic Position: Chr17, 18.7 cM, cytoband C
• Alliance: Ddr1^tm1Wfv page

Skull comparison of Ddr1^tm1Wfv/Ddr1^tm1Wfv, Ddr2^tm1Kln/Ddr2^tm1Kln and Ddr2^tm1Kln/Ddr2⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68368
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1-12 were deleted and replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of embryonic protein extracts. (J:68368)

Expression

In Mice Carrying this Mutation:	28 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddr1 Mutation: 35 strains or lines available

References

• Original: J:68368 Vogel WF, et al., Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development. Mol Cell Biol. 2001 Apr;21(8):2906-17
• All: 29 reference(s)