Six4^tm1Kwk
Targeted Allele Detail

Summary

• Symbol: Six4^tm1Kwk
• Name: sine oculis-related homeobox 4; targeted mutation 1, Kiyoshi Kawakami
• MGI ID: MGI:2388027
• Synonyms: Six4^LacZ
• Gene: Six4 Location: Chr12:73146383-73160201 bp, - strand Genetic Position: Chr12, 30.36 cM
• Alliance: Six4^tm1Kwk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69010
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region of exon 1 encoding the Six homologous region and homeobox was replaced with an in-frame lacZ-neo cassette via homologous recombination. Northern blot analysis of RNA from whole E11.5 homozygous mutant embryos and adult skeletal muscle did not detect gene transcripts of any size. (J:69010)

Expression

In Mice Carrying this Mutation:

33 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six4 Mutation: 36 strains or lines available

References

• Original: J:69010 Ozaki H, et al., Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development. Mol Cell Biol. 2001 May;21(10):3343-50
• All: 13 reference(s)