Map6^tm1Job
Targeted Allele Detail

Summary

• Symbol: Map6^tm1Job
• Name: microtubule-associated protein 6; targeted mutation 1, Didier Job
• MGI ID: MGI:2388040
• Synonyms: STOP-
• Gene: Map6 Location: Chr7:98916654-98986344 bp, + strand Genetic Position: Chr7, 54.05 cM, cytoband E2-F1
• Alliance: Map6^tm1Job page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79099
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 1 was disrupted with a cassette containing lacZ and neo genes. Protein was undetected by Western blot analysis of brain extracts from homozygous mutant mice. (J:79099)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map6 Mutation: 47 strains or lines available

Notes

ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺) or AT1 (129S2/SvPasIco, now called 129S2/SvPasCrl by Charles River).

References

• Original: J:79099 Andrieux A, et al., The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders. Genes Dev. 2002 Sep 15;16(18):2350-64
• All: 18 reference(s)