Cx3cl1^tm1Lira
Targeted Allele Detail

Summary

• Symbol: Cx3cl1^tm1Lira
• Name: C-X3-C motif chemokine ligand 1; targeted mutation 1, Sergio A Lira
• MGI ID: MGI:2388041
• Synonyms: fractalkine-
• Gene: Cx3cl1 Location: Chr8:95498808-95509055 bp, + strand Genetic Position: Chr8, 46.79 cM
• Alliance: Cx3cl1^tm1Lira page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68831
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis of brain mRNA from homozygous mutant animals did not detect gene expression. Immunohistochemical analysis of brain sections from homozygous animals confirmed the absence of gene expression. (J:68831)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cx3cl1 Mutation: 35 strains or lines available

References

• Original: J:68831 Cook DN, et al., Generation and analysis of mice lacking the chemokine fractalkine. Mol Cell Biol. 2001 May;21(9):3159-65
• All: 13 reference(s)