Cx3cl1^tm1Lira
Targeted Allele Detail

Summary

• Symbol: Cx3cl1^tm1Lira
• Name: C-X3-C motif chemokine ligand 1; targeted mutation 1, Sergio A Lira
• MGI ID: MGI:2388041
• Synonyms: fractalkine-
• Gene: Cx3cl1 Location: Chr8:95498808-95509055 bp, + strand Genetic Position: Chr8, 46.79 cM
• Alliance: Cx3cl1^tm1Lira page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68831
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis of brain mRNA from homozygous mutant animals did not detect gene expression. Immunohistochemical analysis of brain sections from homozygous animals confirmed the absence of gene expression. (J:68831)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Cx3cl1^tm1Lira/Cx3cl1^tm1Lira	involves: 129S/SvEv * C57BL/6
hm2	Cx3cl1^tm1Lira/Cx3cl1^tm1Lira	involves: C57BL/6
hm3	Cx3cl1^tm1Lira/Cx3cl1^tm1Lira	Not Specified
cx4	Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Ifc/Ccr2^tm1Ifc Cx3cl1^tm1Lira/Cx3cl1^tm1Lira	B6.Cg-Apoe^tm1Unc Cx3cl1^tm1Lira Ccr2^tm1Ifc

Phenotypes:

Affected Systems	hm1	hm2	hm3	cx4
show or hide all annotated terms
behavior/neurological	N
behavior/neurological phenotype	N
cardiovascular system				√
decreased susceptibility to atherosclerosis				√
cellular			√
increased susceptibility to dopaminergic neuron neurotoxicity			√
hematopoietic system	N	√		√
hematopoietic system phenotype	N
decreased monocyte cell number		√		√
homeostasis/metabolism			√
increased susceptibility to dopaminergic neuron neurotoxicity			√
immune system	N	√		√
immune system phenotype	N
decreased monocyte cell number		√		√
nervous system	N		√
nervous system phenotype	N
increased susceptibility to dopaminergic neuron neurotoxicity			√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cx3cl1 Mutation: 35 strains or lines available

References

• Original: J:68831 Cook DN, et al., Generation and analysis of mice lacking the chemokine fractalkine. Mol Cell Biol. 2001 May;21(9):3159-65
• All: 14 reference(s)