Dgke^tm1Ngb
Targeted Allele Detail

Summary

• Symbol: Dgke^tm1Ngb
• Name: diacylglycerol kinase, epsilon; targeted mutation 1, Nicolas G Bazan
• MGI ID: MGI:2388044
• Synonyms: DGKepsilon-
• Gene: Dgke Location: Chr11:88926005-88951644 bp, - strand Genetic Position: Chr11, 54.34 cM, cytoband C
• Alliance: Dgke^tm1Ngb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68824
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 of the gene was replaced with a neomycin resistance cassette via homologous recombination. The targeted mutation results in deletion of the translation initiation codon, the entire first C1 domain, and most of the second C1 domain. (J:68824)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dgke Mutation: 45 strains or lines available

References

• Original: J:68824 Rodriguez de Turco EB, et al., Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl- inositol lipid signaling. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4740-5
• All: 8 reference(s)