Efnb3^tm1Nwg
Targeted Allele Detail

Summary

• Symbol: Efnb3^tm1Nwg
• Name: ephrin B3; targeted mutation 1, Nicholas W Gale
• MGI ID: MGI:2388046
• Synonyms: ephrin-B3^-
• Gene: Efnb3 Location: Chr11:69444918-69451031 bp, - strand Genetic Position: Chr11, 42.8 cM
• Alliance: Efnb3^tm1Nwg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68814
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 1 was deleted and replaced with a lacZ-PGK-neo cassette. Northern blot analysis of brain mRNA from homozygous mutant animals confirmed the absence of gene expression. However, the lacZ gene was not expressed as originally intended. (J:68814)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efnb3 Mutation: 11 strains or lines available

References

• Original: J:68814 Kullander K, et al., Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. Genes Dev. 2001 Apr 1;15(7):877-88
• All: 10 reference(s)