Pou2af1^tm1Pmt
Targeted Allele Detail

Summary

• Symbol: Pou2af1^tm1Pmt
• Name: POU domain, class 2, associating factor 1; targeted mutation 1, Patrick Matthias
• MGI ID: MGI:2388055
• Synonyms: OBF-1-, OcaB-
• Gene: Pou2af1 Location: Chr9:51125008-51151380 bp, + strand Genetic Position: Chr9, 27.95 cM
• Alliance: Pou2af1^tm1Pmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35827
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding regions of exons 2 through 5 were replaced by a neo cassette inserted by homologous recombination. In all, sequence encoding 250 of the 256 amino acids was deleted. Transcript was undetected by Northern blot analysis of total spleen RNA obtained from 4 week old homozygous mutant mice. (J:35827)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou2af1 Mutation: 15 strains or lines available

References

• Original: J:35827 Schubart DB, et al., B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. Nature. 1996 Oct 10;383(6600):538-42
• All: 16 reference(s)