Fgfr3^tm1.1Iwa
Targeted Allele Detail

Summary

• Symbol: Fgfr3^tm1.1Iwa
• Name: fibroblast growth factor receptor 3; targeted mutation 1.1, Tomoko Iwata
• MGI ID: MGI:2388062
• Synonyms: Fgf3^K644M, SADDAN
• Gene: Fgfr3 Location: Chr5:33879068-33894412 bp, + strand Genetic Position: Chr5, 17.83 cM, cytoband B
• Alliance: Fgfr3^tm1.1Iwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70061
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutation: Nucleotide substitutions
• Mutation details: Fgfr3^tm1Iwa animals carry a lysine to methionine substitution at residue 644 (K644M) of exon 10 and a floxed neo cassette in intron 10. The neo cassette was removed by crossing Fgfr3^tm1Iwa mutants to the cre expressing line, TgN(EIIa-cre)C5379Lmgd. Northern blot analysis of brain RNA from mutant animals showed a similar level of gene expression as wild-type. (J:70061)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr3 Mutation: 54 strains or lines available

References

• Original: J:70061 Iwata T, et al., Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice. Hum Mol Genet. 2001 Jun 1;10(12):1255-64
• All: 2 reference(s)