Igh-J^tm1Jkbv
Targeted Allele Detail

Summary

• Symbol: Igh-J^tm1Jkbv
• Name: immunoglobulin heavy chain, joining region; targeted mutation 1, Aya Jakobovits
• MGI ID: MGI:2388068
• Synonyms: deltaJH
• Gene: Igh-J Location: unknown Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70038
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: The entire Igh-J region and a flanking DQ52 gene segment was deleted and replaced with a neomycin resistance gene via homologous recombination. Homozygous mutant animals were confirmed by Southern blot analysis. (J:70038)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh-J Mutation: 13 strains or lines available

Notes

This allele is used in the Xenomouse strains.

References

• Original: J:70038 Jakobovits A, et al., Analysis of homozygous mutant chimeric mice: deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2551-5
• All: 9 reference(s)