Sst^tm1Low
Targeted Allele Detail

Summary

• Symbol: Sst^tm1Low
• Name: somatostatin; targeted mutation 1, Malcolm J Low
• MGI ID: MGI:2388093
• Synonyms: Smst^-
• Gene: Sst Location: Chr16:23708323-23709708 bp, - strand Genetic Position: Chr16, 15.0 cM, cytoband cen-C3
• Alliance: Sst^tm1Low page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70016
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the promoter region and exon 1 with a PGK-neo cassette. Radioimmunoassay was unable to detect protein product from stomach and brain extracts from homozygous mutant animals. (J:70016)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sst Mutation: 37 strains or lines available

References

• Original: J:70016 Low MJ, et al., Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth. J Clin Invest. 2001 Jun;107(12):1571-80
• All: 15 reference(s)