Akap12^{Gt(ble-lacZ)15Brr}
Gene trapped Allele Detail

Summary

• Symbol: Akap12^{Gt(ble-lacZ)15Brr}
• Name: A kinase anchor protein 12; gene trap 15, Jacqueline Barra
• MGI ID: MGI:2388095
• Gene: Akap12 Location: Chr10:4216380-4309470 bp, + strand Genetic Position: Chr10, 2.06 cM
• Alliance: Akap12^{Gt(ble-lacZ)15Brr} page

Mutation origin

• Mutant Cell Line: TL15
• Germline Transmission: Earliest citation of germline transmission: J:70587
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Modified isoform(s), Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing a phleomycin resistance gene (ble) and lacZ randomly inserted into the endogenous locus, creating the TL15 mutant ES cell line. RT-PCR analyses indicated that the insertion disrupted transcription of the nervous system predominant transcript, while transcription of the testis-specific transcript was largely unaffected. (J:36630, J:70587)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akap12 Mutation: 215 strains or lines available

References

• Original: J:70587 Camus A, et al., Gene trap insertion reveals two open reading frames in the mouse SSeCKS gene: the form predominantly detected in the nervous system is suppressed by the insertion while the other, specific of the testis, remains expressed. Mech Dev. 2001 Jul;105(1-2):79-91
• All: 3 reference(s)