Sstr2^tm1Rgs
Targeted Allele Detail

Summary

• Symbol: Sstr2^tm1Rgs
• Name: somatostatin receptor 2; targeted mutation 1, Roy G Smith
• MGI ID: MGI:2388099
• Synonyms: sst2^-, SSTR2-
• Gene: Sstr2 Location: Chr11:113510168-113516854 bp, + strand Genetic Position: Chr11, 79.05 cM
• Alliance: Sstr2^tm1Rgs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43192
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 1.2 kb of coding region was deleted and replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Northern blot analysis of brain RNA from homozygous mutant animals using a full-length cDNA probe. (J:43192)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sstr2 Mutation: 33 strains or lines available

References

• Original: J:43192 Zheng H, et al., Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons. Mol Endocrinol. 1997 Oct;11(11):1709-17
• All: 19 reference(s)