Amph^tm1Pdc
Targeted Allele Detail

Summary

• Symbol: Amph^tm1Pdc
• Name: amphiphysin; targeted mutation 1, Pietro De Camilli
• MGI ID: MGI:2388118
• Gene: Amph Location: Chr13:19132524-19335089 bp, + strand Genetic Position: Chr13, 6.89 cM
• Alliance: Amph^tm1Pdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75306
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was disrupted by the insertion of a neomycin selection cassette. Protein was undetected by Western blot analysis and immunofluorescence staining. (J:75306)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Amph Mutation: 51 strains or lines available

References

• Original: J:75306 Di Paolo G, et al., Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Neuron. 2002 Feb 28;33(5):789-804
• All: 4 reference(s)