Slc31a1^tm1Djt
Targeted Allele Detail

Summary

• Symbol: Slc31a1^tm1Djt
• Name: solute carrier family 31, member 1; targeted mutation 1, Dennis J Thiele
• MGI ID: MGI:2388121
• Synonyms: Ctr1^-/-
• Gene: Slc31a1 Location: Chr4:62278964-62310006 bp, + strand Genetic Position: Chr4, 33.11 cM, cytoband C1-C2
• Alliance: Slc31a1^tm1Djt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69897
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene was deleted and replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant embryos were observed at day E10.5, but not did not survive past day E12.5. (J:69897)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc31a1 Mutation: 40 strains or lines available

References

• Original: J:69897 Lee J, et al., Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6842-7
• All: 4 reference(s)