Fxr2^tm1Cgr
Targeted Allele Detail

Summary

• Symbol: Fxr2^tm1Cgr
• Name: FMR1 autosomal homolog 2; targeted mutation 1, Ben Oostra
• MGI ID: MGI:2388128
• Synonyms: Fxr2 -
• Gene: Fxr2 Location: Chr11:69523816-69544123 bp, + strand Genetic Position: Chr11, 42.86 cM
• Alliance: Fxr2^tm1Cgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75389
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 7 and surrounding intronic sequence was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis of testis and brain tissue, as well as immunohistochemical analysis, indicated an absence of protein in homozygous mutant mice. (J:75389)

Expression

In Mice Carrying this Mutation:

53 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fxr2 Mutation: 36 strains or lines available

References

• Original: J:75389 Bontekoe CJ, et al., Knockout mouse model for Fxr2: a model for mental retardation. Hum Mol Genet. 2002 Mar 1;11(5):487-98
• All: 10 reference(s)